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The purpose-of this study was to further clarify and examine gender differences and spirituality levels on health favoring behaviors, overall well-being, and life satisfaction in a college student population. The sample consisted of 127 Framingham State University students, with a relatively even number of men and women. Each read either a positive or negative scenario depicting hypothetical friends facing stressful situations and rated anticipated coping responses. Participants also completed self-report questionnaires on coping optimism, self- actualization, health locus of control, life satisfaction, and spirituality, as well as demographic items. Results showed that participants with high spirituality reported high levels of optimism and control of their health, and the amount of exercise in one week Further, there was a gender and spirituality difference in recommendations for the use of positive cognitive and positive social coping in both negative and positive scenarios.