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Low density lipoprotein (LDL) subfractions containing a higher proportion of small dense LDL are associated with higher risk for coronary artery disease and is a characteristic of individuals diagnosed with the Metabolic Syndrome and insulin resistance. Diet composition affects lipoprotein particle distribution, in particular, the distribution of large and small LDL particles. Evidence in the literature suggests that a very low carbohydrate diet reduces the number of small LDL particles and favors a greater distribution of large LDL particles. The purpose of this study is to investigate whether isocaloric diets varying in carbohydrate composition (low, med, high) will affect lipoprotein particle distribution and particle number (especially LDL) independent of weight-loss. We hypothesize that due to changes in lipoprotein metabolism, VLDL, LDL, and HDL particle size and distribution and particle number will be different at the end of weigh loss and maintenance phases of the (FS)2 study.

Publication Date

Summer 8-20-2016


Nutrition, Diet, Obesity, Food Study, FS2, Grant Funding


Food Science | Human and Clinical Nutrition

Effect of Modified Dietary Carbohydrate Intake on Lipoprotein Subclass Distribution and Particle Number in the Framingham State Food Study