Title

A Vitamin/Nutriceutical Formulation Improves Memory and Cognitive Performance in Community-dwelling Adults without Dementia

Document Type

Article

Publication Date

3-2010

Version

Citation

Publication Title

Journal of Nutrition, Health and Aging

Keywords

Acetylcarnitine/pharmacology, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Dementia, Dietary Supplements, Double-Blind Method, Female, Folic, Acid/pharmacology, Humans, Institutionalization, Learning/drug effects, Male, Memory/drug effects, Middle Aged, Reference ValuesS-Adenosylmethionine/pharmacology, Vitamin B 12/pharmacology, Vitamin E/pharmacology, Vitamins/pharmacology, Young Adult

Subject Categories

Nursing

Abstract

Adults of both genders without dementia consumed a nutriceutical formulation ("NF," consisting of folic acid, B12, Vitamin E, S-adenosylmethionine, N-acetyl cysteine and Acetyl-L-carnitine), previously shown to improve cognitive performance in Alzheimer's disease, or placebo. Participants receiving NF but not placebo improved statistically and clinically in the California Verbal Learning Test II and the Trail-Making Test. Both groups improved further during a 3-month open-label extension. Additional individuals displayed identical improvement during a separate 6-month open-label trial. Performance declined to baseline following withdrawal of NF, and statistically improved when participants resumed taking NF. Additional participants receiving NF but not placebo demonstrated improvement within 2 weeks in Trail-making and Digit-Memory tests; both groups improved in a 2-week open-label extension. An increased percentage of participants > or = 74 years of age did not show improvement with NF, which may relate to age-related difficulties in adsorption and/or basal nutritional deficiencies, or age-related cognitive decline during the course of this study. These findings support the benefit of nutritional supplements for cognitive performance and suggest that additional supplementation may be required for the elderly.

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